Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity Amylyx is seeking a highly motivated, detail-oriented, and experienced individual to join our fast-paced team as Manager, Procurement Operations. This newly created position will be part of a growing Procurement & Strategic Sourcing team and support Amylyx’s Procurement Operations function. Reporting into the Sr. Director, Procurement & Strategic Sourcing, the ideal candidate will have excellent interpersonal and problem-solving skills as well as previous experience in a global commercial life sciences organization. We anticipate hiring the Manager, Procurement Operations in September 2026. Responsibilities * Executes the Purchase Order Management process for services and goods, including training and supporting internal stakeholders, issuing Purchase Orders to service providers and suppliers, tracking order status, resolving invoice discrepancies, and closing out Purchase Orders. * Owns the new service provider/supplier set-up and supplier master data maintenance process * Drives continuous improvement efforts in the Procure to Pay (P2P) process and implements solutions to streamline and enhance efficiency, accuracy, and appropriate approvals * Supports report generation and Purchasing data analysis * Oversees training documentation and communication of Procurement policies, processes and practices to educate business partners * Ensures compliance with Amylyx policies and procedures as well as adherence to SOX controls * Performs other duties as assigned Required Qualifications * Bachelor’s degree * 3–5 years of experience in procurement, with a focus on sourcing and purchasing services. * Experience working within a GxP-regulated environment is highly desirable. * Demonstrated knowledge of Purchasing principles, processes, and practices * Experience with ERP systems, NetSuite experience a plus * Hands-on team player and fast learner with great time management skills * Proficient in Microsoft 365 applications Preferred Requirements * Competence in communicating and collaborating with business partners in various departments as well as service providers / suppliers in multiple industries * Prior experience in life sciences pharma or biotech preferred * Experience in prioritizing and managing multiple tasks/projects to meet deadlines Work Location and Conditions * At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. * You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. * You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $125,000—$141,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.