Salary Band: $205,000-$240,000 Location: Downtown Boston, MA  Position Overview The Senior Principal Scientist will provide technical leadership of analytical development within the CMC function across the Antares portfolio. Analytical Development is responsible for analytical activities spanning late-stage discovery (lead optimization and candidate nomination) through early clinical development and late-stage commercial readiness for small molecule programs. This individual will ensure success across drug substance and drug product deliverables by effectively leveraging internal and external resources, while driving strategic and scientific alignment of analytical development activities with overall program needs. The ideal candidate brings a strong track record of leadership, mentorship, and technical achievement within matrixed environments, and will act as a recognized leader in the scientific community—capable of resolving complex technical challenges while advancing innovative solutions across programs. Key Responsibilities * Provide technical leadership and strategic direction for analytical development activities across programs * Lead analytical efforts supporting drug substance and drug product development from discovery through commercial readiness * Ensure successful execution of analytical deliverables by leveraging internal capabilities and external partners (e.g., CDMOs/CROs) * Drive alignment between analytical development strategies and overall program objectives * Lead and contribute to cross-functional teams, effectively managing technical issues and risks within a matrix environment * Maintain and advance state-of-the-art scientific and technical expertise, applying innovative approaches to solve complex challenges * Provide oversight and review of analytical development documentation to support regulatory submissions * Establish and manage project plans, timelines, budgets, and resource allocation for analytical activities * Build and maintain strong internal and external collaborations, including partnerships with CDMOs and technical stakeholders Qualifications * PhD in chemistry, chemical technologies, or related field with 15+ years of relevant industry experience in analytical development within biotech or pharmaceutical settings * Demonstrated expertise in phase-appropriate small molecule analytical method development and validation * Extensive knowledge of advanced analytical principles and laboratory techniques for drug substance and drug product, including application of control strategies across all stages of development * Experience with pre-development activities, including pre-formulation, solid state characterization, and formulations for animal studies * Strong understanding of quality and regulatory guidelines, with experience supporting analytical sections of regulatory submissions * Proven ability to lead in cross-functional matrix environments, set clear goals, and manage tasks, resources, and priorities * Excellent written and verbal communication skills, with strong organizational, planning, and technical problem-solving capabilities * Demonstrated ability to implement new technologies and innovative approaches within development programs * Experience developing and managing project plans, timelines, and budgets across internal and external teams * Proven track record of building effective collaborations with CDMOs, technical leads, and project teams * Prior experience mentoring and potentially managing direct reports The anticipated annual salary range for this position is $205,000-$240,000 annually. The actual salary offered will be based on a number of factors, including but not limited to the qualifications of the applicant, years of relevant experience, level of education attained, certifications or other professional licenses held, and if applicable, the location in which the applicant lives and/or from which they will be performing the job.