Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity The Associate Director, Media Strategy & Execution will lead the development of integrated media and channel strategies that connect business priorities to measurable patient and healthcare professional engagement. This role will guide how paid, owned, earned, and emerging digital channels work together across the customer journey, ensuring media investment is aligned to brand objectives, audience needs, budget priorities, and performance outcomes. You will partner closely with brand, commercial, web, CRM, content, analytics, IT, legal, privacy, and agency teams to build agile, compliant, data-informed digital journeys for both patients and HCPs. The role requires a strategic operator who can translate insights into actionable media plans, manage investment tradeoffs, strengthen measurement discipline, and continuously optimize the channel ecosystem to improve relevance, efficiency, and business impact. Responsibilities * Develop connected media and channel strategies across paid, owned, earned, CRM, web, search, social, programmatic, video/CTV, endemic, non-endemic, and emerging digital channels, ensuring integration with creative, messaging, audience segmentation, and digital experience design * Translate brand objectives, audience insights, market dynamics, and customer needs into clear channel recommendations and journey-led media plans that support awareness, education, diagnosis, treatment consideration, adherence, and ongoing engagement * Partner with brand teams to advise on the creation of compelling, compliant, audience-appropriate content while ensuring alignment with regulatory requirements * Design and execute KOL and community influencer programs in partnership with brand teams to extend compliant education, engagement, and audience reach. Measure performance using audience engagement and downstream behavior signals to inform optimization and future investment decisions * Lead annual, quarterly, and in-cycle media planning processes, including budget allocation, prioritization, and optimization across brands, audiences, channels, and campaign objectives * Make data-informed recommendations on channel mix, investment levels, and funding tradeoffs based on business goals, audience opportunity, market conditions, and performance trends * Manage media budgets in partnership with brand teams, finance, procurement, agencies, and media operations, ensuring spend is transparent, efficient, compliant, and aligned to approved plans * Use performance data, audience quality indicators, reach and frequency, attribution concepts, media mix insights, web analytics, CRM signals, and campaign learnings to identify actionable opportunities * Translate complex data into clear insights and recommendations for marketing leaders, brand teams, and cross-functional stakeholders * Define success measures, dashboards, reporting inputs, and learning agendas in partnership with analytics and brand stakeholders * Champion a test-and-learn culture, including experimentation, personalization pilots, audience refinement, creative testing, channel optimization, and continuous improvement of media effectiveness * Serve as a strategic media partner to commercial leaders, brand teams, analytics, IT and MLR * Lead agency collaboration across media strategy, planning, activation, performance reporting, optimization, innovation, and budget stewardship * Support compliant execution in a regulated environment by partnering with legal, privacy, medical, regulatory, and operational stakeholders as appropriate * Influence stakeholders through clear storytelling, structured recommendations, strong business acumen, and evidence-based decision-making Required Qualifications * Bachelor’s degree required * 8+ years of experience in media strategy, channel strategy, digital marketing, omnichannel engagement, marketing analytics, or related commercial disciplines in the life sciences industry * Experience developing integrated media strategies across digital-first ecosystems, including search, social, programmatic, video/CTV, endemic and non-endemic media, web, CRM, email, and marketing automation channels * Demonstrated experience managing media budgets, agency partners, vendor relationships, investment planning, and performance accountability * Strong understanding of patient and HCP engagement, digital journey planning, customer segmentation, content ecosystems, and compliant marketing practices * Experience building measurement frameworks, defining KPIs, interpreting campaign performance, and using analytics to guide optimization and business decisions * Proven ability to operate in a matrixed organization, influence senior stakeholders, manage ambiguity, and drive cross-functional initiatives from strategy through execution * Knowledge of U.S. healthcare marketing, including patient, HCP, payer, and broader healthcare ecosystem dynamics * Familiarity with media measurement approaches such as attribution, marketing mix modeling, incrementality testing, audience quality analysis, and dashboarding * Hands-on experience with media platforms, web analytics, BI tools, CRM platforms, marketing automation tools, clean rooms, and healthcare media data partners * Experience designing, creating, and optimizing content for Meta platforms and other social channels, with an understanding of platform-specific formats, audience behaviors, creative best practices, and compliant healthcare marketing considerations * Strong financial acumen, analytical orientation, project management discipline, communication skills, and curiosity for emerging media, AI-enabled discovery, and digital engagement innovation Work Location and Conditions * At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. * Preference will be given to candidates residing in the New England area who are able to come onsite as needed * You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. * You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $173,000—$203,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Director, Media Strategy & Execution

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