About Acrivon Therapeutics, Inc. Acrivon is a clinical stage biopharmaceutical company discovering and developing precision medicines utilizing its proprietary Generative Phosphoproteomics AP3 platform. The platform allows the company to interpret and quantify compound specific, drug-regulated pathway activity levels inside the intact cell in an unbiased manner, yielding terabytes of proprietary data and delivering rapid, actionable insights. The AP3 platform is comprised of a growing suite of powerful, internally-developed tools, including the AP3 Data Portal, converting multimodal data into structured data for generative AI analyses, the AP3 Kinase Substrate Relationship Predictor and the AP3 Interactome. These distinctive capabilities enable the company to go beyond the limitations of traditional drug discovery, as well as current AI-based target-centric drug discovery and rapidly design highly differentiated compounds with desirable pathway effects through intracellular protein network analyses and advance these agents into the clinic for streamlined development. Acrivon is currently advancing its lead program, ACR-368 (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial for EC. The company has received Fast Track designation from the Food and Drug Administration, or FDA, for the investigation of ACR-368 as a monotherapy based on OncoSignature-predicted sensitivity in patients with EC. The FDA has granted a Breakthrough Device designation for the ACR-368 OncoSignature assay for the identification of patients with endometrial cancer who may benefit from ACR-368 treatment. In addition to ACR-368, Acrivon is also leveraging its proprietary Generative AI-driven Phosphoproteomics AP3 platform for developing its co-crystallography-driven, internally discovered pipeline programs. These include ACR-2316, a novel, potent, selective WEE1/PKMYT1 inhibitor designed for superior single-agent activity. The Phase 1/2 study of ACR-2316 is advancing in a randomized dose expansion study. Initial data has shown a highly differentiated, favorable safety profile primarily limited to only transient, mechanism-based hematological adverse events, predominantly only neutropenia. Clinical activity has been observed across multiple tumor types, including SCLC, squamous NSCLC and lung adenocarcinoma, tumor types not shown sensitive to current single-agent WEE1 or PKMYT1 inhibitors. Durable clinical activity has been observed, with certain lung cancer subjects remaining on treatment more than one year. In addition, the company is in early IND-enabling studies with several potential first-in-class development candidates targeting CDK11. Position Overview: Acrivon is seeking an experienced, eloquent, highly organized, and talented professional to join our team. This individual will provide executive administrative support, primarily to the CEO, as well as other C-level team members on an as needed basis. The individual must demonstrate a high degree of sophistication, tact, and discretion for dealing with information of a critical and confidential nature and be an advocate and credible representative for Acrivon and the CEO. S/he will provide extensive coordination and communication with both external parties, includinginvestment bankers, analysts, investors, collaborators, and other outside parties, as well as with Board members and the internal teamacross multiple geographies and time zones. In addition to strong interpersonal skills, to succeed in this role, the individual must have outstanding computer and troubleshooting skills, particularly with Microsoft Word, Excel, PowerPoint, and virtual meeting tools such as Zoom and Teams. This individual must thrive in a fast-paced, fluid, and rapidly evolving corporate environment, and be adept at multi-tasking, yet detail-oriented with the ability to follow through and complete tasks in a timely and structured manner. The candidate will also from time to time be expected to make him/herself available for urgent matters if needed outside normal business hours, for instance in situations of travel disruptions, urgent financing or filing matters. The individual must be a solution-oriented team player, whose actions exemplify integrity, dependability, adaptability, and self-confidence. This position is fully on site, five days per week, at Acrivon’s headquarters in Watertown, MA. Duties and Responsibilities: * Provide calendar management for primarily the CEO and secondarily the CFO for analyst, investor, and other company-critical meetings, as well as other C-level team members, as needed, often involving multiple parties, stakeholders, and time zones. * Prioritize inquiries and requests while troubleshooting conflicts; make judgements and recommendations to ensure smooth day-to-day engagements. * Manage meeting logistics, e.g., conference room reservations, AV/IT arrangements, catering, greeting guests, etc.; work with meeting participants to ensure that materials are provided in advance and print if needed. * Collaborate with internal team members, and other administrative assistants to ensure smooth workflows and efficient operations. * Owns and manages the scheduling and administrative preparations for the quarterly and annual Board and committee meetings. * Comfortable and experienced with investor and bank analyst interactions and communication. Familiar with key stakeholders in investment ecosystem including investment bankers, equity research analysts, investors, corporate access, etc. * Help coordinate complex domestic and international travel; including travel itinerary and ensuring passport/visa/countries entry and exit requirements are met. * Assists with preparation of reports and presentations. * Performs other related duties as assigned. Required Skills/Abilities: * Life Sciences or Biotech experience with 5+ years supporting C-suite executives, ideally including support of CEO in a publicly traded biotech company. * Detailed and accurate calendar management, follow-through on tasks to completion, and detailed, timely expense reporting and management (ideally with Concur) are essential. * Excellent verbal and written communication skills. * Structured, with exceptional organizational skills and attention to detail. * Excellent time management skills with a proven ability to meet deadlines and follow through with completion of tasks. * Strong IT and computer skills, with the ability to efficiently work on applicable Microsoft platforms, including Microsoft Word, Excel and PowerPoint. * Ability to function well in a high-paced environment. * Strong interpersonal skills; “ambassador” to both internal and external stakeholders. * Self-starter; demonstrates resourcefulness with proven ability to anticipate needs and manage multiple tasks. * Critical thinker; demonstrates outstanding judgment and problem-solving capabilities. * Comfortable navigating ambiguity and shifting priorities. * Flexible “can do” attitude; able to adapt and reprioritize to shifting or competing priorities. * High level of judgment and discretion related to sensitive and confidential information. * Motivated by working in a fast-paced, dynamic environment. * Availability to work outside of normal business hours when business needs require it. Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.

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