Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. THE TEAM Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here. Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Our Vision * Pursue large scientific challenges that cannot be pursued in conventional environments * Enable individual investigators to pursue their riskiest and most innovative ideas * Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease. THE OPPORTUNITY The Advanced Single Cell Technologies group provides critical single cell profiling and perturbation assays, technology, and expertise to the Biohub NY community. The goal of the platform is to develop cutting-edge single-cell technologies in collaborations related to studying human disease and the interaction of immune cells with human organs. More information can be found on the lab website (https://biohub.org/single-cell-technology-platform/). The R&D Engineer II will create new technologies and devices for high throughput single-cell screening and will have demonstrated experience in designing, prototyping, testing and troubleshooting diagnostic or point-of-care medical devices. We are seeking a creative, methodical, resourceful, and technically rigorous engineer capable of driving projects independently and on a team. This role sits at the intersection of device engineering, cell biology/immunology, and reagent formulation, and requires an ability to own a problem end-to-end, from proof-of-concept demonstration to prototype and beyond. This role offers substantial design freedom with direct lab access for rapid testing. WHAT YOU'LL DO * Design, build and test prototypes for point-of-care sample processing, iterating based on performance data and optimizing for reproducibility * Design mechanisms for controlled timing and sequencing of biochemical processes within a device (e.g., controlled reagent release, passive valving, or equivalent) * Perform hands-on preparation and handling of biological specimens, and conduct assay validation experiments (e.g., timing precision, reagent activity, sample/cell quality at endpoint) * Apply domain knowledge across device engineering, cell biology, and materials science to guide hardware design decisions * Establish test protocols and acceptance criteria to ensure reproducible performance across prototype iterations and production lots * Participate in discussions with project collaborators * Carefully document work * Clearly report on project progress * Contribute to scientific publications and patent applications WHAT YOU'LL BRING * Bachelor's or Master’s Degree in Engineering (especially biomedical, chemical or mechanical engineering) plus 5+ years of relevant, post-graduate hands-on engineering experience. Holders of non-engineering degrees must have at least 6 years of hands-on engineering experience developing hardware. * Track record of developing diagnostic or point-of-care medical devices * Experience with handling biological samples * Proficiency in CAD * Experience with 3D printing and rapid prototyping * Ability to independently design rigorous experiments, troubleshoot complex workflows, and drive projects to completion * Strong documentation habits * Collaborative mindset and strong scientific communication skills Nice to have * Wet lab experience (cell culture, basic molecular biology) * Experience with reagent stabilization/lyophilization or dried-reagent formulation * Knowledge of and proficiency in Python * Experience with microfluidics and microfabrication COMPENSATION The New York City, NY base pay range for a new hire in this role is $153,000 - $191,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role. BETTER TOGETHER As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. BENEFITS FOR THE WHOLE YOU We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. * Provides a generous employer match on employee 401(k) contributions to support planning for the future. * Paid time off to volunteer at an organization of your choice. * Funding for select family-forming benefits. * Relocation support for employees who need assistance moving If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

R&D Engineer II

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