POSITION SUMMARY: Korro Bio is seeking an experienced Senior Scientist to lead our HTS-NGS team in support of our oligonucleotide platform and portfolio projects. This is a hybrid leadership and hands-on role that requires a combination of scientific expertise, team management, and cross-functional collaboration. The ideal candidate brings deep technical knowledge in high-throughput cell assays and NGS workflows, along with leadership experience, to lead a key workflow in the identification of RNA editing therapeutics. KEY RESPONSIBILITIES: Team Leadership • Lead and mentor a team of scientists performing in vitro biological screening and NGS-based characterization of oligonucleotide therapeutics. • Set team priorities, coordinate workloads, and ensure timely, high-quality delivery against corporate milestones. • Foster a collaborative, growth-oriented team culture with a focus on scientific rigor and operational excellence. Assay Development & Optimization • Design, develop, and optimize end-to-end molecular biology and NGS workflows, including amplicon-seq and RNA-seq. • Establish and maintain robust high-throughput cell-based assay platforms in 96- and 384-well formats, including transfection protocols. • Apply systematic troubleshooting approaches to resolve technical challenges and continuously improve assay performance. Automation & Technology Integration • Lead the design, troubleshooting, and qualification of automated liquid handling workflows to maximize throughput and reproducibility. • Evaluate and implement new instrumentation and technologies to enhance the capabilities of the HTS-NGS platform, eventually developing a fully automated system. • Oversee QC instrumentation usage and data integrity across the team (Qubit, TapeStation, Fragment Analyzer). Cross-Functional Collaboration • Partner closely with Chemistry, Data Science, and Biology teams to align assay outputs with downstream analytical needs and project objectives. • Communicate results clearly and proactively to stakeholders across functions, including through written reports and presentations. Operational & Data Management • Champion LIMS adoption and data quality standards using Benchling. • Utilize project management tools (e.g. Jira / Confluence) to track progress, manage timelines, and communicate status. REQUIRED QUALIFICATIONS: • PhD with 4+ years, MS with 12+ years or equivalent industry experience in cell biology, molecular biology, genomics, or a related field. • Prior experience in a biotech or pharmaceutical environment is required. • Demonstrated track record of managing scientists to achieve research and operational goals. • Hands-on expertise with cell culture in 96- and 384-well formats, including transfection methodologies. • Comprehensive end-to-end NGS experience: amplicon-seq, RNA-seq, library preparation, QC, and sequencing run execution. Expertise with Illumina sequencing platforms preferred (MiSeq). • Expertise in core molecular biology techniques: RNA/DNA isolation, PCR/qPCR, and gel electrophoresis. • Experience with liquid handling automation systems, including Viaflo 96/384, HiRes/Certus Flex, and/or Tempest. • LIMS experience, preferably with Benchling. • Exceptional attention to detail and commitment to data quality and scientific reproducibility. • Strong written and verbal communication skills; ability to distill complex technical information for diverse audiences. • Collaborative team player who thrives in a dynamic, cross-functional biotech environment. PREFERRED QUALIFICATIONS: • Experience with project management tools such as Jira and Confluence. • Familiarity with QC instrumentation: Qubit, TapeStation, and Fragment Analyzer. • Experience with screening siRNA, antisense oligonucleotides, or similar constructs a strong plus.

Senior Scientist

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