Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity Amylyx is seeking an experienced and business-oriented compliance leader to serve as Vice President, Compliance.  Reporting to the Senior Vice President, Deputy General Counsel & Compliance Officer, this individual will help design, implement, and continuously enhance a comprehensive healthcare compliance program as the company prepares for commercial launch and rapid growth. The Vice President, Compliance will play a critical leadership role in fostering a culture of integrity and accountability, establishing a launch-ready compliance infrastructure, and serving as a trusted advisor to business leaders across the organization. The successful candidate will combine strategic vision with operational excellence, demonstrating the ability to build programs, influence stakeholders, and execute effectively in a dynamic biotechnology environment. We anticipate hiring the VP, Compliance in September 2026 Responsibilities * Build a compliance program consistent with industry standards and regulatory expectations, including policies and procedures, training and communications, auditing and monitoring, investigations, corrective actions, and ongoing risk assessment. * Partner with the Executive Leadership Team and Board to establish and reinforce a strong tone from the top, embedding compliance and ethical conduct into leadership communications, business operations, strategic initiatives, and organizational culture. * Drive the Company’s Compliance Committee and compliance reporting to the Board and Audit Committee. * Serve as a strategic advisor to commercial, medical, and other functions to ensure launch activities are conducted in compliance with applicable legal, regulatory, and industry requirements. * Build compliance operations, including transparency reporting, fair market value processes, grants and sponsorship review, third-party due diligence, conflict-of-interest processes, investigations, and monitoring activities. * Conduct compliance investigations and ensure appropriate corrective and preventive actions are implemented. * Develop and lead the Company's compliance training and communications strategy, translating legal and regulatory requirements into practical, business-relevant guidance. * Conduct ongoing compliance risk assessments and periodically evaluate the effectiveness of the Company's compliance culture, recommending enhancements based on business needs, emerging risks, and regulatory expectations. * Partner with the Deputy General Counsel to execute and evolve the Company’s Enterprise Risk Management program. * Help build and mentor a high-performing compliance organization and foster a culture of collaboration, accountability, and continuous improvement. Required Qualifications * Bachelor’s degree required; Juris Doctor, Masters and/or Compliance Certification (CCEP), or comparable professional qualifications strongly preferred. * Minimum 12 years of relevant healthcare compliance experience in the biotechnology, pharmaceutical, medical device, and/or life sciences industry, with demonstrated experience designing, implementing, and/or enhancing healthcare compliance programs. * Experience supporting one or more U.S. pharmaceutical product launches preferred. * Excellent leadership and interpersonal skills, a problem-solving mindset, and ability to thrive in a fast-paced environment. * Excellent project management skills with the ability to manage multiple priorities simultaneously and drive execution. * Strong oral and written communication and presentation skills, and professionalism to handle sensitive matters confidentially and with discretion. * Demonstrated commitment to ethics, integrity, and values-based leadership. * Ability to travel approximately 15-20% of time. Work Location and Conditions * At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. * You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. * You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $298,000—$335,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.